What's it like in Otay Mesa?

Otay Mesa is a neighbourhood that travellers like for its beaches, restaurants and shopping.

Where is the best hotel for a stay in Otay Mesa?

Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa .

How many hotels will I find in the Otay Mesa area?

Expedia has 5 Otay Mesa hotels and other accommodation options, and one might make a good home base for venturing out into the greater San Diego area.

If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?

Yes! Most room reservations are refundable provided that you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you booked a non-refundable reservation, it might still be possible to cancel it and be given a refund within a 24-hour period of booking. Add dates, click "Search", then filter by "fully refundable" to view top deals in Otay Mesa.

What is there to do in this San Diego neighbourhood?

A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.

Top 10 Otay Mesa Hotels of 2025

Top 10 Hotels in Otay Mesa

Welcome to Holiday Inn Express & Suites, featuring a modern design with a lush entrance area and a prominent address sign.

"Great stay, close to the Cross Border Xpress "

includes taxes & fees

10 Aug - 11 Aug

Relax by the pool with lounge chairs and umbrellas, surrounded by a low wall.

"Very accommodating. We had to leave before official breakfast time but staff brought out food for us."

includes taxes & fees

16 Jul - 17 Jul

Relax by the ocean with a clear view from this pool area, surrounded by lounge chairs and tables under the shade of palm trees.

"Great location, Great Staff and really clean."

includes taxes & fees

3 Aug - 4 Aug

Relax in a comfortable seating area surrounded by lush greenery and a bar.

"The area was amazing, food & shopping options were right across the hotel which was very convenient. Amenities were great, complimentary breakfast had good options, and staff were friendly. "

includes taxes & fees

20 Jul - 21 Jul

Welcome to our hotel, set amidst beautifully maintained gardens with a clear path leading to the main building.

"Great place to stay! "

includes taxes & fees

6 Aug - 7 Aug

Guests can enjoy waterfront views and access to a dock area with sailboats.

"Trip and location was amazing."

includes taxes & fees

20 Jul - 21 Jul

Relax by the resort pool surrounded by lounge chairs and umbrellas, with a clear view of the surrounding landscape.

"A good place to stay with the whole family"

includes taxes & fees

10 Aug - 11 Aug

"Great location, and nice hotel."

includes taxes & fees

20 Jul - 21 Jul

Enjoy a tranquil marina view from your balcony, complete with a table for two.

"The views and location were perfect! "

includes taxes & fees

7 Aug - 8 Aug

Relax in the hotel's central seating area, surrounded by a staircase and reception desk.

"Room was clean, a great location and every single staff I had an interaction with was super nice! "

6 restaurants, breakfast, lunch, dinner served; seafood

"Enjoyed our stay"

includes taxes & fees

14 Aug - 15 Aug

Experience the grandeur of our lobby, featuring a stunning chandelier, elegant marble floor, and a beautifully designed reception desk.

"We enjoyed the roof top area and coffee for guest to have while enjoying the view."

includes taxes & fees

20 Jul - 21 Jul

Welcome to our lobby, featuring a spacious area with a central counter, pendant lights, and a tropical mural.

"Very comfortable beds, gorgeous water view, front desk staff was wonderful. "

includes taxes & fees

3 Aug - 4 Aug

Enjoy a comfortable stay in this stylish room with two beds, a flat-screen TV, and a desk area.

"Good location, clean and friendly staff"

includes taxes & fees

20 Jul - 21 Jul

Relax by the pool surrounded by lush greenery and comfortable seating options.

"Great location, friendly staff!"

Relax in a spacious room with a large bed, flat-screen TV, and city view.

"great place to stay"

includes taxes & fees

20 Jul - 21 Jul

Relax and socialize in our elegantly furnished bar area, featuring a variety of seating options and a selection of beverages.

"Would stay there again when in town"

Enjoy waterfront views and access to the marina from this scenic destination.

"Friendly staff."

includes taxes & fees

11 Aug - 12 Aug

Enjoy casual outdoor dining and socializing in this inviting patio area with tables, chairs, and lush greenery.

"Great location, friendly staff!"

includes taxes & fees

17 Jul - 18 Jul

Experience the vibrant city life from our corner location, with stunning views of the surrounding streets.

"Great location, good breakfast, clean rooms"

includes taxes & fees

20 Jul - 21 Jul

Where to stay in Otay Mesa

Find the best Otay Mesa areas for the activities you enjoy most.

Downtown San Diego

2 out of top 10 points of interest in this area

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

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Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

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Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

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Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

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