Otay Mesa Car Rental

Search and Compare from Car Companies in Otay Mesa

Compare car suppliers to unlock big savings, and package your flight, hotel, and car to save even more.

Members save 10% more on select hotels, cars, activities and holiday rentals. Sign up.Opens in a new window

Enjoy maximum flexibility with penalty-free cancellation on most car rentals.

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Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

What happens if I need to cancel my Otay Mesa car reservation?
No need to worry. You should be eligible for a total refund if you notify us at least six hours prior to picking up the car. Your confirmation contains information about this, as does our Customer Service Portal. Not all prepaid reservations will receive a refund though, so it’s a good idea to read through the rental policy.
Why should I rent an Otay Mesa car with Expedia?
From quick work trips to cross-country journeys, Expedia has vehicles to suit every style and adventure. Take your pick of quality rental companies in Otay Mesa. And with our competitive offers and discounts, you can be confident you’ll get a terrific deal on your set of wheels. Did you know you can combine your bookings into a vacation package? Add a flight or hotel to your rental car and watch the savings grow!
How do I find the best car rental deals in Otay Mesa with Expedia?
Check reviews and ratings, choose your favorite ride and compare offers from the most popular brands. Expedia makes it easy to find the best deal on your rental wheels. Combine your Otay Mesa car rental with flight or hotel bookings and drive off with even greater savings.
What do you need to rent a car in Otay Mesa?
Renting a car in Otay Mesa is easy. Usually, all you’ll need is your driver’s license and a credit card in the same name. After selecting your favorite set of wheels, check your policy to make sure there are no extra requirements prior to your scheduled pickup.
Can I rent a car for a month or longer in Otay Mesa?
Whether you have plans to stop in Otay Mesa or travel beyond, it’s easy to reserve a long-term rental with Expedia. Enter your trip details and pick-up/drop-off locations and we’ll help you find incredible long-term car rental deals.
Where can I find an Otay Mesa car rental if I am younger than 25?
The ability to rent a vehicle if you are under 25 in Otay Mesa often depends on the rental company you select. Some businesses apply a surcharge for drivers between 21 and 24 years old, whereas other companies may not have any additional fees for this age bracket. It’d be good to go through the terms and conditions of your prospective car rental dealer to escape any nasty surprises at the rental desk.