Hotels in Serra Mesa

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
23 Jul - 24 Jul
Tomorrow
24 Jul - 25 Jul
This weekend
25 Jul - 27 Jul
Next weekend
1 Aug - 3 Aug

Filter by

Guest rating
Guest rating
Property class

Top 10 Hotels in Serra Mesa

Sycuan Casino Resort
3 outdoor pools, pool cabanas (surcharge), pool umbrellas

Sycuan Casino Resort

4.0 star property
9.2 out of 10, Wonderful, (1423)
"Great place to stay beautiful casino! "
Sycuan Casino Resort
Days Inn by Wyndham San Diego-East/El Cajon
Desk, laptop workspace, iron/ironing board, free WiFi

Days Inn by Wyndham San Diego-East/El Cajon

2.0 star property
7.6 out of 10, Good, (1009)
"Cozy bed, very quiet and convenient"
The price is S$156
includes taxes & fees
17 Aug - 18 Aug
Days Inn by Wyndham San Diego-East/El Cajon
Best Western Plus La Mesa San Diego
Lobby

Best Western Plus La Mesa San Diego

2.5 star property
8.2 out of 10, Very good, (1011)
"Staff was friendly, hotel was clean and breakfast was great"
The price is S$173
includes taxes & fees
17 Aug - 18 Aug
Best Western Plus La Mesa San Diego
SpringHill Suites by Marriott Chula Vista Eastlake
Outdoor pool

SpringHill Suites by Marriott Chula Vista Eastlake

3.5 star property
9.6 out of 10, Exceptional, (380)
"Great place and location "
The price is S$230
includes taxes & fees
10 Aug - 11 Aug
SpringHill Suites by Marriott Chula Vista Eastlake
Ramada by Wyndham San Diego Poway Miramar
Exterior

Ramada by Wyndham San Diego Poway Miramar

2.0 star property
7.0 out of 10, Good, (845)
"Our stay went well, and the hotel is a good value"
The price is S$139
includes taxes & fees
24 Aug - 25 Aug
Ramada by Wyndham San Diego Poway Miramar
Sonesta ES Suites San Diego - Rancho Bernardo
Full-sized fridge, microwave, stovetop, dishwasher

Sonesta ES Suites San Diego - Rancho Bernardo

3.0 star property
8.2 out of 10, Very good, (1011)
"Very nice place for families "
The price is S$159
includes taxes & fees
13 Aug - 14 Aug
Sonesta ES Suites San Diego - Rancho Bernardo
Ayres Hotel San Diego South - Chula Vista
Lobby lounge

Ayres Hotel San Diego South - Chula Vista

3.0 star property
9.8 out of 10, Exceptional, (1088)
"Very nice hotel"
The price is S$246
includes taxes & fees
3 Aug - 4 Aug
Ayres Hotel San Diego South - Chula Vista
Heritage Inn La Mesa
Outdoor pool, pool umbrellas, pool loungers

Heritage Inn La Mesa

2.0 star property
6.6 out of 10, (1049)
"Familiar stay"
The price is S$108
includes taxes & fees
30 Jul - 31 Jul
Heritage Inn La Mesa
La Quinta Inn by Wyndham San Diego - Miramar
Reception

La Quinta Inn by Wyndham San Diego - Miramar

3.0 star property
7.4 out of 10, Good, (1015)
"comfortable bed & clean rooms"
The price is S$168
includes taxes & fees
24 Aug - 25 Aug
La Quinta Inn by Wyndham San Diego - Miramar
Lamplighter Inn & Suites at SDSU
Outdoor pool, pool umbrellas, pool loungers

Lamplighter Inn & Suites at SDSU

2.5 star property
9.0 out of 10, Wonderful, (1216)
"Clean rooms, simple checkin, plenty of parking"
Lamplighter Inn & Suites at SDSU
Best Western Chula Vista/Otay Valley Hotel
Lobby

Best Western Chula Vista/Otay Valley Hotel

2.5 star property
7.8 out of 10, Good, (1464)
"Clean, great staff. "
The price is S$166
includes taxes & fees
24 Aug - 25 Aug
Best Western Chula Vista/Otay Valley Hotel
La Quinta Inn by Wyndham San Diego Chula Vista
Exterior

La Quinta Inn by Wyndham San Diego Chula Vista

3.0 star property
8.6 out of 10, Excellent, (1312)
"Love the breakfast and convenient location. "
The price is S$173
includes taxes & fees
29 Jul - 30 Jul
La Quinta Inn by Wyndham San Diego Chula Vista
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Desk, blackout curtains, iron/ironing board, free WiFi

Studio 6 Suites San Ysidro, CA -San Diego South Bay

2.5 star property
7.8 out of 10, Good, (1146)
"Great stay"
The price is S$121
includes taxes & fees
6 Aug - 7 Aug
Studio 6 Suites San Ysidro, CA -San Diego South Bay
Valli Hi Motel
Desk, blackout curtains, soundproofing, free WiFi

Valli Hi Motel

2.5 star property
8.2 out of 10, Very good, (1017)
"Staff was friendly hotel was clean and easy day trips back and forth throughout San Diego area."
Valli Hi Motel
Best Western Americana Inn
1 bedroom, pillow-top beds, in-room safe, desk

Best Western Americana Inn

2.5 star property
9.0 out of 10, Wonderful, (1121)
"It’s a very nice clean and friendly people in the property"
The price is S$178
includes taxes & fees
24 Aug - 25 Aug
Best Western Americana Inn
Chula Vista Inn
Exterior

Chula Vista Inn

2.5 star property
6.6 out of 10, (1007)
"Nice hotel "
Chula Vista Inn
Hotel Palmeras Chula Vista
Front of property

Hotel Palmeras Chula Vista

2.0 star property
7.0 out of 10, Good, (1789)
"Great rooms ,Awesome staff. And pet friendly!!! "
The price is S$108
includes taxes & fees
28 Jul - 29 Jul
Hotel Palmeras Chula Vista
Hercor Hotel - Urban Boutique
1 bedroom, premium bedding, down duvets, pillow-top beds

Hercor Hotel - Urban Boutique

3.0 star property
8.6 out of 10, Excellent, (1212)
"Great place to stay!"
The price is S$142
includes taxes & fees
28 Jul - 29 Jul
Hercor Hotel - Urban Boutique
Howard Johnson by Wyndham National City/San Diego South
Hair dryer, towels

Howard Johnson by Wyndham National City/San Diego South

2.0 star property
7.4 out of 10, Good, (1006)
"Enjoyed our stay"
The price is S$154
includes taxes & fees
10 Aug - 11 Aug
Howard Johnson by Wyndham National City/San Diego South
SureStay Hotel by Best Western Chula Vista San Diego Bay
Outdoor pool

SureStay Hotel by Best Western Chula Vista San Diego Bay

3.0 star property
7.8 out of 10, Good, (1461)
"Great place"
The price is S$151
includes taxes & fees
24 Aug - 25 Aug
SureStay Hotel by Best Western Chula Vista San Diego Bay
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.
Downtown San Diego map

Downtown San Diego

2 out of top 10 points of interest in this area

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Belmont Park featuring a park and rides
Mission Beach map

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Pacific Beach Park which includes a beach
Pacific Beach map

Pacific Beach

The stunning beaches and fantastic nightlife are just a few highlights of Pacific Beach. Make a stop by Mission Bay or Crystal Pier while you're exploring the area.

Gaslamp Quarter featuring street scenes, signage and a bar
Gaslamp Quarter map

Gaslamp Quarter

Cosy bars interesting history and top sights from Gaslamp Museum at the Davis-Horton House to Harlem of the West Sites – discover Gaslamp Quarter, a destination also famous for its shopping.

Ocean Beach map

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Ocean Beach Pier and Dog Beach.

Top Serra Mesa Hotel Reviews

The Little Italy Hotel Downtown San Diego

The Little Italy Hotel Downtown San Diego

10/10 Excellent
"Convenient location "
Juliana 1-night trip
Posted 19 hours ago
The Little Italy Hotel Downtown San Diego

Frequently asked questions

What's it like in Serra Mesa?

Guests are sure to enjoy their time checking out all that San Diego's Serra Mesa neighbourhood has to offer. Consider a visit to Stadium Golf Center & Batting Cages as part of your Serra Mesa travel plans.

How many hotels can I expect to find in the Serra Mesa area?

Expedia has 35 hotels and other accommodation options in Serra Mesa to choose from, making this an ideal home base for exploring the greater San Diego area.

If I need to cancel my hotel reservation in Serra Mesa, will I receive a refund?

Yes, most hotel reservations are fully refundable if cancelled before the accommodation's cancellation deadline, which often is within 24-48 hours of your arrival date. If you have a non-refundable reservation, it may still be possible to cancel it and get a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review top deals in Serra Mesa.

What can I see and do in this San Diego neighbourhood?

Stadium Golf Center & Batting Cages is an attraction you might want to check out while you're in Serra Mesa. When you're sightseeing in San Diego, Convoy District and Old Cactus Garden are also worth a stop.