Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
You can enjoy a tasting or tour at Hunter Valley Winery during your travels to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Explore the mighty Mississippi from the riverfront park where historic murals tell stories of river life. Climb to the top of Academic Hall at Southeast Missouri State or hunt for antiques along downtown's brick-paved streets.
"This is my fav hotel when I pass through Cape Girardeau. Extremely clean, easy on and off Interstate 55, breakfast options galore (including WHOLE WHEAT bagels!)."
"If you’ve never stayed at Drury inn & Suites, they’re great places to stay, and affordable. Staff is always helpful and professional. Drury has their act together"
"We came into town for a concert and had a blast! The hotel was super comfy, and the staff were friendly. The rooms were very clean and the decor was beautiful! "
If I need to cancel my hotel reservation in Cape Girardeau, will I receive a refund?
Yes! You'll find that most hotel reservations are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you may still be able to cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Cape Girardeau.
What's the best accommodation for a budget-friendly stay in Cape Girardeau?
History buffs will enjoy exploring Cape Girardeau, and visitors give high marks for the top-notch restaurants. Tourists who journey to this welcoming city can discover its riverfront, university setting and shopping. In Cape Girardeau, there are 49 hotels and other accommodation options to choose from. Find out more about Cape Girardeau.
What should I do while I'm visiting Cape Girardeau?
The hottest months are usually July and August, with an average temperature of 25°C, while the coldest months are January and February, with an average of 5°C. Average annual precipitation for Cape Girardeau is 1495 mm.