There are several airlines that operate frequent flights from Madrid (MAD) to Brussels (BRU) including

• IBERIA with 247 flights a week
• Air Europa with 74 flights a week
• British Airways with 57 flights a week
• Lufthansa Cargo with 36 flights a week
• Air Berlin with 35 flights a week

The earliest flight leaves Adolfo Suarez Madrid Barajas Airport at 06:20 and arrives at Brussels Airport at 08:35. The last flight of the day departs Madrid at 21:10 and arrives at Brussels at 23:25.

The flight distance from Madrid to Brussels is about 1323 km, the shortest flight is 02 hours 15 minutes with Vueling Airlines."

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