There are several airlines that operate frequent flights from Lisbon (LIS) to Cairo (CAI) including

• TAP Portugal with 94 flights a week
• Lufthansa Cargo with 42 flights a week
• Alitalia with 37 flights a week
• Egyptair with 25 flights a week
• Singapore Airlines with 9 flights a week

The earliest flight leaves Portela Airport at 00:15 and arrives at Cairo Intl. Airport at 00:40. The last flight of the day departs Lisbon at 23:50 and arrives at Cairo at 21:35.

The flight distance from Lisbon to Cairo is about 4383 km, the shortest flight is 07 hours with Air Europa.

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