There are several airlines that operate frequent flights from Cairo (CAI) to Frankfurt (FRA) including

• Egyptair with 165 flights a week
• Lufthansa Cargo with 37 flights a week
• Turkish Airlines with 36 flights a week
• Aegean Airlines with 17 flights a week
• Austrian Airlines with 14 flights a week

The earliest flight leaves Cairo Intl. Airport at 02:20 and arrives at Frankfurt Intl. Airport at 05:50. The last flight of the day departs Cairo at 15:10 and arrives at Frankfurt at 19:35.

The flight distance from Cairo to Frankfurt is about 2936 km, the shortest flight is 04 hours 25 minutes with Tunisair.

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