Find Luxury Hotels in Southeast Missouri

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southeast Missouri Luxury Hotels

Top Luxury Hotels in Southeast Missouri

We don't have any properties that match your exact search

Recommended hotels in Southeast Missouri

Drury Inn & Suites Sikeston, MO
Relax in the serene courtyard, surrounded by lush greenery and comfortable seating.

Drury Inn & Suites Sikeston, MO

3.0 star property
9.4 out of 10, Exceptional, (1000)
"Always the best hotel in any town. "
The price is S$150
includes taxes & fees
20 Jul - 21 Jul
Drury Inn & Suites Sikeston, MO
Postcard Cabins St. Francois
Situated in a wooded area, this cabin features a cozy outdoor space with a porch, bench, fire pit, and table.

Postcard Cabins St. Francois

2.0 star property
10.0 out of 10, Exceptional, (13)
"I couldn’t have found a more perfect place for a much needed escape! The location was peaceful and relaxing, the cabin was clean, and I slept better than ever. I’m going back in two weeks and can’t wait!"
The price is S$198
includes taxes & fees
17 Jul - 18 Jul
Postcard Cabins St. Francois
The Riverview
Relax in a stylish room with two beds, a desk, and a city view.

The Riverview

2.0 star property
9.4 out of 10, Exceptional, (328)
"Wonderful place to stay. Very clean and affordable!"
The price is S$152
includes taxes & fees
13 Jul - 14 Jul
The Riverview
Sam A Baker State Park
Situated in a snowy forest, this cabin features a cozy front porch and a chimney.

Sam A Baker State Park

2.0 star property
The price is S$170
includes taxes & fees
26 Jul - 27 Jul
Sam A Baker State Park
Hampton Inn Cape Girardeau I 55 East
Relax in style with comfortable seating and social tables amidst a clean, modern space.

Hampton Inn Cape Girardeau I 55 East

2.5 star property
9.6 out of 10, Exceptional, (722)
"Great place to stay convenient walking to multiple restaurants"
The price is S$158
includes taxes & fees
27 Jul - 28 Jul
Hampton Inn Cape Girardeau I 55 East
The Farmstead Hotel
Welcome to our reception area, featuring a large entrance, digital display, and elegant chandelier.

The Farmstead Hotel

2.5 star property
8.8 out of 10, Excellent, (376)
"Great stay!"
The price is S$130
includes taxes & fees
23 Jul - 24 Jul
The Farmstead Hotel
EC Reed's Mercantile and Hotel
Relax in a serene bedroom with a large bed, flat-screen TV, and stylish bedside tables.

EC Reed's Mercantile and Hotel

3.0 star property
9.6 out of 10, Exceptional, (75)
"Great, clean room and the restaurant attached was delicious- best breakfast! "
EC Reed's Mercantile and Hotel
Pear Tree Inn Sikeston
Relax in the spacious lobby with a mezzanine level, comfortable seating, and large windows.

Pear Tree Inn Sikeston

2.5 star property
9.4 out of 10, Exceptional, (1002)
"Great place to stay with kids "
The price is S$132
includes taxes & fees
13 Jul - 14 Jul
Pear Tree Inn Sikeston
Tru By Hilton Cape Girardeau
Enjoy a spacious room with a large bed, desk, and seating area, featuring a flat-screen TV and a desk lamp.

Tru By Hilton Cape Girardeau

2.5 star property
9.6 out of 10, Exceptional, (39)
"Nice quiet place to stay, staff was super polite"
The price is S$147
includes taxes & fees
16 Jul - 17 Jul
Tru By Hilton Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.