Southeast Missouri Holidays

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    Better together

    Save up to S$134 when you book a flight and hotel together*
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    Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Rest easy

    Plan, book, and manage your trip all in one place

Top hotels in Southeast Missouri

Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is S$82 per night from 3 Aug to 4 Aug
S$82
3 Aug - 4 Aug
includes taxes & fees
8/10 Very Good! (1,005 reviews)
"Overall great place. Would stay again"

Reviewed on 9 Jul, 2025

Baymont Inn and Suites by Wyndham Farmington, MO
The Riverview
The Riverview
2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is S$152 per night from 15 Jul to 16 Jul
S$152
15 Jul - 16 Jul
includes taxes & fees
9.2/10 Wonderful! (334 reviews)
"Very nice place to stay. Close to restaurants and easy access."

Reviewed on 11 Jul, 2025

The Riverview
Drury Plaza Hotel Cape Girardeau Conference Center
Drury Plaza Hotel Cape Girardeau Conference Center
3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is S$130 per night from 20 Jul to 21 Jul
S$130
20 Jul - 21 Jul
includes taxes & fees
9.4/10 Exceptional! (1,008 reviews)
Great stay
"Awesome hotel. Beds are comfortable. Rooms are quiet. Breakfast was awesome."

Reviewed on 13 Jul, 2025

Drury Plaza Hotel Cape Girardeau Conference Center
See all 580 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Popular places to visit

Lake Wappapello

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Lake Wappapello

What to do in Southeast Missouri

St Louis: City Museum General Admission Ticket

St Louis: City Museum General Admission Ticket

S$29
per adult
96% of travellers recommend
St Louis: City Museum General Admission Ticket
St. Louis Arch Walking Tour and Entrance Ticket

St. Louis Arch Walking Tour and Entrance Ticket

S$64
per adult
St. Louis Arch Walking Tour and Entrance Ticket
St Louis art museum

St. Louis Narrated Trolley Tour

S$38
per adult
94% of travellers recommend
St. Louis Narrated Trolley Tour
See all activities in Southeast Missouri

Frequently asked questions

How much does a Southeast Missouri holiday package cost?
Cross off another part of the world with our Southeast Missouri holiday packages, which start from just . Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri holiday packages. You'll find deals on flights, hotels, tours and more that'll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you'll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Centre and Pear Tree Inn Cape Girardeau West are a couple of favourites. If you're considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri holiday?
It's tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can't book ahead, don't worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Holidaying for a week or two? Look into a rental car, hotel and flight bundle. If you're taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you've made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you'll pick up terrific discounts. Whether you're planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia holiday package?
You can, and with over 550 airlines to pick from around the world, you're spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri holiday package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you've booked your Southeast Missouri holiday package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.