Southeast Missouri Holidays

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    Save up to S$134 when you book a flight and hotel together*
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Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.
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Top hotels in Southeast Missouri

Motel 6 Poplar Bluff, MO
Motel 6 Poplar Bluff, MO
2 out of 5
4101 Highway 67 N, Poplar Bluff, MO
Fully refundableReserve now, pay when you stay
The price is S$106 per night from 24 Nov to 25 Nov
S$106
includes taxes & fees
24 Nov - 25 Nov
7.8/10 Good! (1,001 reviews)
"We've been here before the table in the room wasn't clean"

Reviewed on 19 Nov,2024

Motel 6 Poplar Bluff, MO
Baymont Inn and Suites by Wyndham Farmington, MO
Baymont Inn and Suites by Wyndham Farmington, MO
2.5 out of 5
1625 W Columbia St, Farmington, MO
Fully refundableReserve now, pay when you stay
The price is S$80 per night from 3 Dec to 4 Dec
S$80
includes taxes & fees
3 Dec - 4 Dec
7.8/10 Good! (796 reviews)
"Would stay here again"

Reviewed on 19 Nov,2024

Baymont Inn and Suites by Wyndham Farmington, MO
Pear Tree Inn Cape Girardeau West
Pear Tree Inn Cape Girardeau West
2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is S$109 per night from 8 Dec to 9 Dec
S$109
includes taxes & fees
8 Dec - 9 Dec
9/10 Wonderful! (1,001 reviews)
"Clean room. Great help at the front desk. Continental breakfast is a little lacking."

Reviewed on 19 Nov,2024

Pear Tree Inn Cape Girardeau West
See all 530 properties in Southeast Missouri
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Southeast Missouri holiday package cost?
Cross off another part of the world with our Southeast Missouri holiday packages, which start from just . Select the flights and hotels that match your travel plans. Then, add on one or two tours or experiences for an unforgettable adventure.
How do I get a cheap travel package to Southeast Missouri?
Browse and book everything in the one place with our Southeast Missouri holiday packages. You’ll find deals on flights, hotels, tours and more that’ll keep your pocket happy and your adventurous spirit alive. And, with more than 550 partner airlines and 1,000,000 hotels around the world to select from, you’ll have endless opportunities to mix and match your own way.
What are the top hotels in Southeast Missouri?
When it comes to properties in Cape Girardeau, Drury Plaza Hotel Cape Girardeau Conference Centre and Pear Tree Inn Cape Girardeau West are a couple of favourites. If you’re considering heading to Ste Genevieve, City Place St. Louis Downtown and The Branson Hillside Hotel are waiting to welcome you.
How far in advance should I book my Southeast Missouri holiday?
It’s tricky picking the perfect time for airfares, but we generally say the earlier, the better. Many international journeys on Expedia become available up to a year in advance. If you can’t book ahead, don’t worry. Cheap prices appear from time to time within a few weeks of departure dates.
What does an Expedia Southeast Missouri travel package include?
From hotels and flights to car rentals, Expedia can help you craft a Southeast Missouri package that fits you. Holidaying for a week or two? Look into a rental car, hotel and flight bundle. If you’re taking a quick break, a hotel and airfare deal may suit you better. Experiences can also be added once you’ve made your booking. Our packages make it a breeze to plan and save.
What should I know before booking a Southeast Missouri travel package?
When you book your flights, hotels and car rentals together, you’ll pick up terrific discounts. Whether you’re planning a beach escape in a villa or prefer to stay in a comfortable hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Southeast Missouri Expedia holiday package?
You can, and with over 550 airlines to pick from around the world, you’re spoiled for choice. Have a look through the available options and see which airline best suits your budget and needs.
If I'm not able to travel, can I cancel my Southeast Missouri holiday package?
Because we understand life is full of surprises, the answer is yes. To learn more, head to our Customer Service Portal. But generally speaking, if you’ve booked your Southeast Missouri holiday package in the last 24 hours, you may be able to cancel or change it for no charge. Your hotel, airline or car rental company may charge a fee if your booking is older than that.

Popular places to visit

Lake Wappapello

Lake Wappapello

Commune with nature and explore the great outdoors at Lake Wappapello during your travels in Wappapello. While in this family-friendly area, you can enjoy the restaurants.

Lake Wappapello

What to do in Southeast Missouri

St. Louis: Gateway Ghouls and Hauntings Walking Tour

St. Louis: Gateway Ghouls and Hauntings Walking Tour

S$34
Per adult
St. Louis: Gateway Ghouls and Hauntings Walking Tour
St Louis: 75-Minute City Trolley Tour

St Louis: 75-Minute City Trolley Tour

S$39
Per adult
St Louis: 75-Minute City Trolley Tour
Private and Group training for all level of skills

Bullets & BBQ at Indoor Shooting Range in St. Louis County

S$230
Per adult
Bullets & BBQ at Indoor Shooting Range in St. Louis County
See all activities in Southeast Missouri

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.