Smallpox Island
Visit Smallpox Island
Popular places to visit
Lincoln Douglas Square
Stand in the presence of U.S. history, on the spot where Lincoln and Douglas debated as statesmen two years prior to a presidential race that changed everything.
Alton Prison
See the remains of a prison which was built over 150 years ago and which housed Confederate prisoners during the Civil War.
Riverview Park
Explore the great outdoors at Riverview Park, a lovely green space in Alton. Visit the shops in this family-friendly area or simply enjoy its restaurants.
Piasa Park
Explore the great outdoors at Piasa Park, a lovely green space in Alton. Visit the shops in this family-friendly area or simply enjoy its restaurants.
National Great Rivers Museum
Next to the wide Mississippi River is a museum filled with activities and displays explaining the history and importance of the river.
Argosy Casino
Why not try your luck with a visit to Argosy Casino during your travels in Alton? Visit the shops in this family-friendly area or simply enjoy its restaurants.
Top Smallpox Island Hotel Deals
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- Holidays and getaways similar to Smallpox Island
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- More Hotel Options in Smallpox Island
- Moonrise Hotel
- Drury Plaza Hotel St. Louis at the Arch
- 21C Museum Hotel St Louis
- Angad Arts Hotel
- Embassy Suites by Hilton St. Louis Downtown
- Clayton Plaza Hotel & Extended Stay
- Holiday Inn St. Louis - Downtown Conv Ctr, an IHG Hotel
- The Last Hotel
- Ameristar Casino Resort and Spa
- The West End
- The Royal Sonesta Chase Park Plaza St. Louis
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.