There are several airlines that operate frequent flights from Seattle (SEA) to Panama (PTY) including

• Delta Air Lines with 111 flights a week
• Alaska Airlines with 90 flights a week
• United Airlines with 69 flights a week
• American Airlines with 57 flights a week
• COPA Airlines with 29 flights a week

The earliest flight leaves Seattle Tacoma Intl. Airport at 00:01 and arrives at Tocumen Intl. Airport at 06:05. The last flight of the day departs Seattle at 23:59 and arrives at Panama at 22:30.

The flight distance from Seattle to Panama is about 6448 km, the shortest flight is 08 hours 59 minutes with United Airlines.

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