There are several airlines that operate frequent flights from Chicago (ORD) to Osaka (KIX) including

• United Airlines with 47 flights a week
• American Airlines with 28 flights a week
• Japan Airlines with 17 flights a week
• Air China with 17 flights a week
• Malaysia Airlines with 13 flights a week

The earliest flight leaves O'Hare Intl. Airport at 00:20 and arrives at Kansai Intl. Airport at 08:00. The last flight of the day departs Chicago at 23:55 and arrives at Osaka at 22:00.

The flight distance from Chicago to Osaka is about 12053 km, the shortest flight is 16 hours 35 minutes with United Airlines.

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