There are several airlines that operate frequent flights from Manila (MNL) to Osaka (KIX) including

• Philippine Airlines with 41 flights a week
• All Nippon Airways with 24 flights a week
• China Airlines with 18 flights a week
• EVA Airways with 16 flights a week
• China Eastern Airlines with 9 flights a week

The earliest flight leaves Ninoy Aquino Intl. Airport at 00:15 and arrives at Kansai Intl. Airport at 05:15. The last flight of the day departs Manila at 15:05 and arrives at Osaka at 19:55.

The flight distance from Manila to Osaka is about 2648 km, the shortest flight is 03 hours 40 minutes with Philippine Airlines.

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