There are several airlines that operate frequent flights from Orlando (MCO) to San Francisco (SFO) including

• American Airlines with 228 flights a week
• Delta Air Lines with 201 flights a week
• with 197 flights a week
• United Airlines with 124 flights a week
• Qantas Airways with 95 flights a week

The earliest flight leaves Orlando Intl. Airport at 06:15 and arrives at San Francisco Intl. Airport at 09:03. The last flight of the day departs Orlando at 19:15 and arrives at San Francisco at 22:15.

The flight distance from Orlando to San Francisco is about 3948 km, the shortest flight is 05 hours 37 minutes with .

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