There are several airlines that operate frequent flights from Madrid (MAD) to Frankfurt (FRA) including

• IBERIA with 386 flights a week
• Air Berlin with 87 flights a week
• Air Europa with 76 flights a week
• British Airways with 67 flights a week
• Lufthansa Cargo with 53 flights a week

The earliest flight leaves Adolfo Suarez Madrid Barajas Airport at 06:10 and arrives at Frankfurt Intl. Airport at 08:40. The last flight of the day departs Madrid at 20:00 and arrives at Frankfurt at 22:40.

The flight distance from Madrid to Frankfurt is about 1429 km, the shortest flight is 02 hours 30 minutes with Vueling Airlines."

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