There are several airlines that operate frequent flights from Johannesburg (JNB) to San Francisco (SFO) including

• SAA with 74 flights a week
• United Airlines with 42 flights a week
• Lufthansa Cargo with 21 flights a week
• British Airways with 15 flights a week
• Delta Air Lines with 13 flights a week

The earliest flight leaves O.R. Tambo Intl. Airport at 12:30 and arrives at San Francisco Intl. Airport at 07:55. The last flight of the day departs Johannesburg at 23:59 and arrives at San Francisco at 16:30.

The flight distance from Johannesburg to San Francisco is about 18363 km, the shortest flight is 23 hours 18 minutes with Virgin Atlantic.

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