There are several airlines that operate frequent flights from Sao Paulo (GRU) to Cancun (CUN) including

• COPA Airlines with 42 flights a week
• LATAM Airlines Brasil with 36 flights a week
• American Airlines with 27 flights a week
• LATAM Airlines Group with 23 flights a week
• AVIANCA with 22 flights a week

The earliest flight leaves Guarulhos Governor Andre Franco Montoro Intl. Airport at 00:30 and arrives at Cancun Intl. Airport at 05:50. The last flight of the day departs Sao Paulo at 23:55 and arrives at Cancun at 21:54.

The flight distance from Sao Paulo to Cancun is about 7236 km, the shortest flight is 10 hours 35 minutes with Turkish Airlines."

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