There are several airlines that operate frequent flights from Frankfurt (FRA) to Prague (PRG) including

• Lufthansa Cargo with 172 flights a week
• Swiss International Air Lines with 30 flights a week
• Air Berlin with 23 flights a week
• Hainan Airlines with 13 flights a week
• Czech Airlines j.s.c with 11 flights a week

The earliest flight leaves Frankfurt Intl. Airport at 09:00 and arrives at Vaclav Havel Airport at 10:00. The last flight of the day departs Frankfurt at 22:15 and arrives at Prague at 23:15.

The flight distance from Frankfurt to Prague is about 407 km, the shortest flight is 01 hours with TAP Portugal.

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