There are several airlines that operate frequent flights from Guangzhou (CAN) to Chicago (ORD) including

• China Southern Airlines with 131 flights a week
• China Eastern Airlines with 38 flights a week
• Delta Air Lines with 29 flights a week
• Air China with 21 flights a week
• Shenzhen Airlines with 20 flights a week

The earliest flight leaves Baiyun Intl. Airport at 00:05 and arrives at O'Hare Intl. Airport at 04:29. The last flight of the day departs Guangzhou at 23:30 and arrives at Chicago at 21:50.

The flight distance from Guangzhou to Chicago is about 13338 km, the shortest flight is 16 hours 35 minutes with Shenzhen Airlines.

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