There are several airlines that operate frequent flights from Houston (IAH) to Chicago (ORD) including

• United Airlines with 762 flights a week
• Delta Air Lines with 234 flights a week
• American Airlines with 163 flights a week
• Qantas Airways with 28 flights a week
• with 17 flights a week

The earliest flight leaves George Bush Intercontinental Airport at 05:00 and arrives at O'Hare Intl. Airport at 00:07. The last flight of the day departs Houston at 21:45 and arrives at Chicago at 23:53.

The flight distance from Houston to Chicago is about 1496 km, the shortest flight is 02 hours 27 minutes with United Airlines."

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