Search Bed and Breakfast in South Carolina Midlands

Change your mind

Book hotels with free cancellation

Treat yourself

Be picky

Search almost a million properties worldwide

Check prices for these dates

Next weekend

In two weeks

In one month

In two months

Featured B&B in South Carolina Midlands

"If you are ever in Sumter I would highly recommend staying here. A true gem of a house with great facilities."

includes taxes & fees

31 Jul - 1 Aug

"The property is beautiful. The staff and owners are extremely nice and helpful. "

includes taxes & fees

28 Jul - 29 Jul

"Bed was soo comfortable and sheets felt great. Easy entry and parking instructions - easy to be a guest here. Would stay here again and again!"

includes taxes & fees

26 Jul - 27 Jul

"The south at it’s very best. Beautiful, comfortable and welcoming. I only wish that we’d had longer to stay. David was very friendly and accommodating. I can’t recommend this beautiful home strongly enough. Stay here……you’ll love it."

"Elizabeth and Dave were gracious and hospitable, breakfast was delicious, and we would happily return to Inn Upon Moon River!"

includes taxes & fees

29 Jul - 30 Jul

"What an amazing bed and breakfast. Beth is very welcoming and makes you feel right at home. Hardest decision was which breakfast plate I chosen the morning. Definitely will return. Highly recommend "

includes taxes & fees

30 Jul - 31 Jul

"This place is as close as you will ever get to perfection. A perfect match between southern hospitality and beauty! Breakfast was all freshly cooked and delicious. An extra ordinary place of beauty. A must ! Should be on your bucket list."

Save an average of 15% on thousands of hotels when you're signed in

Top South Carolina Midlands Hotel Reviews

La Quinta Inn by Wyndham Columbia NE/Fort Jackson

10/10 Excellent

"Relaxing and convenient "

Howard Johnson by Wyndham Florence

10/10 Excellent

"I recently stayed at Howard Johnson by Wyndham in Florence and had a great experience. The room was clean, well-maintained, and surprisingly spacious. The bed was very comfortable, and the air conditioning worked perfectly—especially important in the Carolina heat! What really stood out was the staff. Everyone I interacted with was friendly, welcoming, and helpful—from check-in to check-out. They made sure I had everything I needed and answered my questions with a smile. The location is convenient, right off the highway, and close to restaurants, gas stations, and stores. It’s a great spot for a stopover or even a short stay while exploring the area."