San Cosme y Damian Hotels from S$118

    Plan, book, stay with confidence
    bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    Sign in
    today icon
    Change your mind
    Book hotels with free cancellation

Check San Cosme y Damian hotel prices

Tonight
21 Nov - 22 Nov
Tomorrow night
22 Nov - 23 Nov
This weekend
22 Nov - 24 Nov
Next weekend
29 Nov - 1 Dec

Filter by

Guest rating
Guest rating
Property class

Top 10 trending San Cosme y Damian hotels

Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.
Unlock Black Friday deals

Frequently asked questions

If I need to cancel my hotel reservation in San Cosme y Damian, will I receive a refund?

Yes! Most hotel bookings are refundable provided that you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you have a reservation that's non-refundable, you might be able to still cancel and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in San Cosme y Damian.

What's it like to stay in San Cosme y Damian?

Visitors can enjoy all that San Cosme y Damian has to offer, including its museums. You'll find 18 Expedia hotels and other accommodation options in the larger area of Encarnacion.

What is there to see in San Cosme y Damian?

A couple of favourite places to visit are Buenaventura Suarez Planetarium and Guarani Jesuit Ruins of San Cosme and San Damián. Take a look at what more there is to see and do in Expedia's San Cosme y Damian guide.

What's the seasonal weather in San Cosme y Damian?

The hottest months are usually January and February, with an average temperature of 26°C, while the coldest months are July and June, with an average of 17°C. The rainiest months in San Cosme y Damian are October, November, May and April, with each month seeing an average of 198 mm of rainfall.