Photo by Amber Palmer

Hotels near Mayo Clinic Florida

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
17 Jul - 18 Jul
Tomorrow
18 Jul - 19 Jul
This weekend
18 Jul - 20 Jul
Next weekend
25 Jul - 27 Jul

Filter by

Guest rating
Guest rating
Property class

Top 10 Hotels Near Mayo Clinic Florida

Residence Inn By Marriott Jacksonville - Mayo Clinic Area
Relax by the fire pit in our outdoor patio area, surrounded by comfortable seating and a modern backdrop.

Residence Inn By Marriott Jacksonville - Mayo Clinic Area

3.0 star property
9.4 out of 10, Exceptional, (407)
"The place was clean and staff was wonderful. Will be staying again!"
The price is S$242
includes taxes & fees
1 Aug - 2 Aug
Residence Inn By Marriott Jacksonville - Mayo Clinic Area
TownePlace Suites by Marriott Jacksonville East
Relax by the fire pit in a cozy outdoor space with a sofa and armchairs.

TownePlace Suites by Marriott Jacksonville East

3.0 star property
9.2 out of 10, Wonderful, (475)
"Close to 95, clean, friendly , lots of parking and close to beach. "
The price is S$177
includes taxes & fees
27 Jul - 28 Jul
TownePlace Suites by Marriott Jacksonville East
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Relax on the patio with a round table and four chairs, surrounded by lush greenery.

Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic

2.5 star property
9.0 out of 10, Wonderful, (1003)
"I loved our stay"
The price is S$172
includes taxes & fees
3 Aug - 4 Aug
Hampton Inn & Suites Jacksonville - Beach Blvd/Mayo Clinic
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Relax in the outdoor seating area, surrounded by comfortable sofas and chairs, a fire pit, and lush greenery.

Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches

3.0 star property
8.4 out of 10, Very good, (725)
"Close to mayo"
The price is S$234
includes taxes & fees
2 Aug - 3 Aug
Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Lobby sitting area

Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG

2.5 star property
8.4 out of 10, Very good, (1010)
"Staff was great and the hotel had been totally refurbished. "
The price is S$162
includes taxes & fees
20 Jul - 21 Jul
Holiday Inn Express & Suites Jacksonville SE- Med Ctr Area by IHG
Element Jacksonville Beach
Relax in our spacious lobby with a comfortable seating area, featuring a reception desk, TV, and plenty of seating options.

Element Jacksonville Beach

3.0 star property
9.6 out of 10, Exceptional, (485)
"It was a clean hotel with fairly comfortable beds. "
The price is S$197
includes taxes & fees
10 Aug - 11 Aug
Element Jacksonville Beach
Holiday Inn Express Jacksonville Beach by IHG
Enjoy a diverse selection of dishes at our self-service buffet, featuring omelets, cheese, and more.

Holiday Inn Express Jacksonville Beach by IHG

2.5 star property
9.2 out of 10, Wonderful, (1001)
"Clean convenient and close to dining "
The price is S$162
includes taxes & fees
20 Jul - 21 Jul
Holiday Inn Express Jacksonville Beach by IHG
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Exterior

Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area

2.5 star property
8.8 out of 10, Excellent, (1002)
"Very nice hotel and great staff"
The price is S$184
includes taxes & fees
31 Jul - 1 Aug
Hampton Inn Jacksonville/Ponte Vedra Beach-Mayo Clinic Area
Salt Air Inn & Suites
Relax in a tranquil outdoor space with a covered seating area, wooden picnic table, and umbrella.

Salt Air Inn & Suites

2.5 star property
9.8 out of 10, Exceptional, (344)
"Great place to stay"
The price is S$233
includes taxes & fees
20 Jul - 21 Jul
Salt Air Inn & Suites
Four Points by Sheraton Jacksonville Beachfront
Experience the beachfront location of Four Points, where a central tower is flanked by two smaller towers, offering stunning ocean views.

Four Points by Sheraton Jacksonville Beachfront

3.0 star property
9.2 out of 10, Wonderful, (1005)
"Very nice for a quick get away"
The price is S$271
includes taxes & fees
10 Aug - 11 Aug
Four Points by Sheraton Jacksonville Beachfront
Ponte Vedra Inn & Club
Experience the grandeur of our lobby, featuring a high ceiling, comfortable seating, and polished stone floors.

Ponte Vedra Inn & Club

5.0 star property
9.4 out of 10, Exceptional, (802)
"We enjoyed our stay Friendly Professional Staff "
The price is S$679
includes taxes & fees
1 Aug - 2 Aug
Ponte Vedra Inn & Club
The Lodge and Club at Ponte Vedra Beach
Relax on the beachfront patio with outdoor seating and umbrellas, taking in the ocean view.

The Lodge and Club at Ponte Vedra Beach

5.0 star property
9.4 out of 10, Exceptional, (670)
"Loved our stay, my sixth at this property. JR the waiter at breakfast at the Inn, was delightful!Cant wait to come back!"
The price is S$751
includes taxes & fees
10 Aug - 11 Aug
The Lodge and Club at Ponte Vedra Beach
Margaritaville Jacksonville Beach
Enjoy a stroll along the beach and take in the views of the ocean from the pier.

Margaritaville Jacksonville Beach

2.5 star property
9.0 out of 10, Wonderful, (2981)
"We loved staying here! The room was very comfortable and the beach walk area was awesome."
Margaritaville Jacksonville Beach
Hampton Inn Jacksonville Beach/Oceanfront
Experience the soothing sound of a naturalistic waterfall, surrounded by lush greenery and a tranquil pool.

Hampton Inn Jacksonville Beach/Oceanfront

3.0 star property
9.2 out of 10, Wonderful, (2324)
"Great location. "
The price is S$255
includes taxes & fees
17 Aug - 18 Aug
Hampton Inn Jacksonville Beach/Oceanfront
Best Western Oceanfront
Guests can enjoy the beach with gentle waves and a clear sky.

Best Western Oceanfront

2.5 star property
9.0 out of 10, Wonderful, (1004)
"Clean, nice property right at the beach with a very good breakfast "
The price is S$192
includes taxes & fees
10 Aug - 11 Aug
Best Western Oceanfront
The Hotel Palms
Relax in a serene space with two beds, a desk for work, and a large window offering a view.

The Hotel Palms

3.5 star property
9.6 out of 10, Exceptional, (287)
"Easy comfy convenient. "
The price is S$275
includes taxes & fees
3 Aug - 4 Aug
The Hotel Palms
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Walk along the boardwalk to the beach, where umbrellas provide shade and a pier extends into the water.

Springhill Suites By Marriott Jacksonville Beach Oceanfront

4.0 star property
9.0 out of 10, Wonderful, (527)
"It was nice, very clean and the staff was great"
The price is S$232
includes taxes & fees
17 Aug - 18 Aug
Springhill Suites By Marriott Jacksonville Beach Oceanfront
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
Welcome to our reception area, featuring a central desk, geometric patterned carpet, and a seating area with tables and chairs.

Holiday Inn Express & Suites Jacksonville - Town Center by IHG

2.5 star property
9.4 out of 10, Exceptional, (1000)
"Clean hotel, would stay here again"
The price is S$168
includes taxes & fees
20 Jul - 21 Jul
Holiday Inn Express & Suites Jacksonville - Town Center by IHG
AC Hotel Jacksonville St Johns Town Center
Enjoy a drink at the stylish bar, surrounded by an array of bottles and comfortable seating.

AC Hotel Jacksonville St Johns Town Center

2.5 star property
9.4 out of 10, Exceptional, (120)
"Great place to stay, easy in/out, nice facilities and plenty to do in the area. "
The price is S$261
includes taxes & fees
18 Jul - 19 Jul
AC Hotel Jacksonville St Johns Town Center
TownePlace Suites by Marriott® Jacksonville Mayport
Front of property – evening/night

TownePlace Suites by Marriott® Jacksonville Mayport

3.0 star property
10.0 out of 10, Exceptional, (8)
"Great looking property with friendly staff. Conveniently located near Naval Station Mayport. Also close enough to get to Jacksonville Beach with a short drive. "
The price is S$172
includes taxes & fees
24 Jul - 25 Jul
TownePlace Suites by Marriott® Jacksonville Mayport
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

What's the area like around Mayo Clinic Florida?

Mayo Clinic Florida is located in a welcoming area of Jacksonville known for its beautiful beaches and surfing. If you're looking for a convenient place to stay, take a look at the 35 hotels and other accommodation options you'll find within a mile.

Where is the best place to stay close to Mayo Clinic Florida?

Adjacent to Mayo Clinic Florida, Courtyard by Marriott Jacksonville at Mayo Clinic Campus/Beaches is one of the top choices for your stay based on our traveller data, and this hotel offers a restaurant and an outdoor pool. Another good choice is Residence Inn By Marriott Jacksonville - Mayo Clinic Area, located just 0.7 mi (1.1 km) away.

How many hotels are there near Mayo Clinic Florida?

Expedia has 35 hotels and other accommodation options within a mile from Mayo Clinic Florida.

If I need to cancel the hotel reservation for my stay near Mayo Clinic Florida, will I receive a refund?

Yes! You'll find that most hotel bookings are fully refundable as long as you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, you may still be able to cancel and get a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the "fully refundable" filter to view the top deals on offer near Mayo Clinic Florida.

What can I see and do near Mayo Clinic Florida?

You can enjoy live performances at Wilson Center For the Arts and Players by the Sea. Spend some time exploring the the natural beauty of Huguenot Park, Oceanfront Park and Gonzales Park. Lounge by the water at Northeast Florida Beaches and Ponte Vedra Beach.