There are several airlines that operate frequent flights from San Francisco (SFO) to Rome (FCO) including

• United Airlines with 131 flights a week
• Delta Air Lines with 102 flights a week
• American Airlines with 101 flights a week
• KLM with 69 flights a week
• Lufthansa Cargo with 59 flights a week

The earliest flight leaves San Francisco Intl. Airport at 06:00 and arrives at Fiumicino Leonardo da Vinci Intl. Airport at 06:45. The last flight of the day departs San Francisco at 21:55 and arrives at Rome at 22:55.

The flight distance from San Francisco to Rome is about 10774 km, the shortest flight is 13 hours 10 minutes with Virgin Atlantic.

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