There are several airlines that operate frequent flights from San Francisco (SFO) to Detroit (DTW) including

• United Airlines with 272 flights a week
• Delta Air Lines with 158 flights a week
• American Airlines with 117 flights a week
• Qantas Airways with 99 flights a week
• with 87 flights a week

The earliest flight leaves San Francisco Intl. Airport at 06:35 and arrives at Detroit Metropolitan Wayne County Airport at 05:53. The last flight of the day departs San Francisco at 23:35 and arrives at Detroit at 21:25.

The flight distance from San Francisco to Detroit is about 3355 km, the shortest flight is 04 hours 21 minutes with .

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