There are several airlines that operate frequent flights from Panama (PTY) to Mexico City (MEX) including

• COPA Airlines with 116 flights a week
• Aeromexico with 63 flights a week
• AVIANCA with 15 flights a week

The earliest flight leaves Tocumen Intl. Airport at 07:32 and arrives at Mexico City Intl. Airport at 00:17. The last flight of the day departs Panama at 21:23 and arrives at Mexico City at 23:08.

The flight distance from Panama to Mexico City is about 2423 km, the shortest flight is 03 hours 54 minutes with COPA Airlines.

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