There are several airlines that operate frequent flights from Chicago (ORD) to Zurich (ZRH) including

• United Airlines with 183 flights a week
• American Airlines with 101 flights a week
• Lufthansa Cargo with 91 flights a week
• Delta Air Lines with 60 flights a week
• British Airways with 51 flights a week

The earliest flight leaves O'Hare Intl. Airport at 14:45 and arrives at Zurich Airport at 06:20. The last flight of the day departs Chicago at 20:15 and arrives at Zurich at 10:55.

The flight distance from Chicago to Zurich is about 7168 km, the shortest flight is 08 hours 20 minutes with United Airlines.

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