Cheap Flights from Chicago to Knoxville

Featured airlines

Singapore Airlines
AirAsia
Scoot
Philippine Airlines
Malaysia Airlines
Thai Airways International
Asiana Airlines
Qatar Airways
Air India
  • Plan, book, fly with confidence
  • trending down icon
    Be in the know
    Get alerts if flight prices drop or rise*
  • bex rewards loyalty icon
    Book smarter
    Save up to 40% on select hotels after you book a flight*
  • payments icon
    Earn twice
    Earn your airline miles on top of our rewards
    Sign in
Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.
Unlock Black Friday deals
Chicago to Knoxville route information
Origin airport
O'Hare Intl.
Destination airport
McGhee Tyson
Distance
760 km

Perfect flights from Chicago to Knoxville

Your Journey from Chicago to Knoxville

Start your unforgettable journey with Expedia. Our broad selection of flights from Chicago to Knoxville caters to every travel need. Whether you're yearning for a romantic escape, a solo adventure, or a cultural immersion, we've got you covered.
 

Choosing Your Ideal Flight

With Expedia, you have access to a wide range of airlines, including . Our selection of flights from O'Hare Intl. to McGhee Tyson caters to every traveler's requirements, ensuring your journey aligns with your schedule. With options from airlines, you're bound to find the perfect flight.
 

Maximizing Value with Chicago to Knoxville Flights

Experience the joy of finding cheap flights from O'Hare Intl. to McGhee Tyson that fit your budget. Keep an eye out for our special deals and discounts, and check our flexible one-way fares and roundtrip prices *.
 

Pre-Flight Essentials

Ensure a smooth journey from Chicago to Knoxville with Expedia. From information about check-in times and in-flight amenities to guidance on baggage policies, we provide all the essentials to prepare you for your flight.
 

Experience the Vibrant Knoxville

Picture yourself stepping off the plane in Knoxville and immersing yourself in the unique atmosphere of . From local markets to cultural festivals, each city offers its distinct charm. Make the most of your trip by exploring local attractions and indulging in the local cuisine. With Expedia, explore all this and more, tailored to your budget.
 

Added Convenience on Your Chicago to Knoxville Flight

Traveling with Expedia is more than just a flight. We offer details about in-flight amenities, baggage policies, and more to ensure a smooth and hassle-free journey. Choose from our variety of airlines and embark on a memorable journey from Chicago to Knoxville.
 

Beyond the Flight – Exploring Knoxville

With Expedia, your adventure extends beyond the flight. Explore Knoxville at your own pace by renting a car or booking a hotel. Discover hidden gems off the beaten path and create unforgettable memories.
 

Book Your Flight from Chicago to Knoxville with Confidence

Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support make your travel experience seamless and stress-free. Embark on your journey from Chicago to Knoxville with confidence. Book your travel arrangements with Expedia today.
 
*Note: Prices may vary based on availability and are subject to change.

Frequently asked questions

How much is a flight from O'Hare Airport to TYS?
Based on airfares listed within the last 7 days on Expedia for flights departing within the next year, round-trip flights between ORD and Knoxville Airport start from . Make your booking ASAP to get the best price for your next big adventure. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from O'Hare Airport to McGhee Tyson Airport (TYS)?
Every airline has different terms and conditions. If you decide to cancel your escape, head to our Customer Service Portal.
How do I find cheap flights from O'Hare Airport to TYS that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you’re searching for O’Hare Airport to TYS flights, you’ll see a “no change fees” filter for you to select.
How far is the flight from O'Hare Airport to TYS?
It’s only 770 kilometres between Chicago and Alcoa. It’s quite possible that you’ll spend more time travelling to and from the airport than you will actually flying!
Which airlines fly direct from ORD to TYS?
There are a few airlines that fly straight from ORD to McGhee Tyson Airport (TYS). United Airlines (UA) is a top choice, offering 121 flights a month. American Airlines (AA) is also worth a look. It offers 60 flights per month. Between these two airlines, you’ll be able to find a good deal from Chicago to Alcoa.
Are O'Hare Intl. Airport (ORD) to TYS flight tickets cheaper when they're purchased at the last minute?
Late planners can occasionally nab a bargain, with some super cheap airfares from ORD to McGhee Tyson Airport (TYS) popping up a few weeks prior to the departure date. If you’d rather book ahead, Expedia compares and updates all the best flight deals regularly — as early as a year in advance in some cases. It depends on the carrier though, as not every airline advertises prices so far in advance.
*Available to Expedia members.