There are several airlines that operate frequent flights from Milan (MXP) to Frankfurt (FRA) including

• Lufthansa Cargo with 55 flights a week
• Swiss International Air Lines with 25 flights a week
• Luxair with 11 flights a week
• Brussels Airlines with 11 flights a week
• Alitalia with 11 flights a week

The earliest flight leaves Malpensa Intl. Airport at 06:35 and arrives at Frankfurt Intl. Airport at 07:55. The last flight of the day departs Milan at 19:15 and arrives at Frankfurt at 20:30.

The flight distance from Milan to Frankfurt is about 492 km, the shortest flight is 01 hours 15 minutes with Brussels Airlines.

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