There are several airlines that operate frequent flights from Mexico City (MEX) to San Francisco (SFO) including

• Aeromexico with 138 flights a week
• Delta Air Lines with 74 flights a week
• Air New Zealand with 64 flights a week
• United Airlines with 59 flights a week
• American Airlines with 56 flights a week

The earliest flight leaves Mexico City Intl. Airport at 05:45 and arrives at San Francisco Intl. Airport at 09:03. The last flight of the day departs Mexico City at 20:20 and arrives at San Francisco at 23:05.

The flight distance from Mexico City to San Francisco is about 3044 km, the shortest flight is 04 hours 40 minutes with Volaris.

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