There are several airlines that operate frequent flights from Mexico City (MEX) to Panama (PTY) including

• Aeromexico with 156 flights a week
• COPA Airlines with 58 flights a week
• AVIANCA with 36 flights a week

The earliest flight leaves Mexico City Intl. Airport at 05:56 and arrives at Tocumen Intl. Airport at 10:34. The last flight of the day departs Mexico City at 16:34 and arrives at Panama at 20:20.

The flight distance from Mexico City to Panama is about 2423 km, the shortest flight is 03 hours 38 minutes with COPA Airlines.

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