There are several airlines that operate frequent flights from Melbourne (MEL) to San Francisco (SFO) including

• Qantas Airways with 90 flights a week
• Singapore Airlines with 52 flights a week
• Air New Zealand with 50 flights a week
• Virgin Australia with 43 flights a week
• American Airlines with 38 flights a week

The earliest flight leaves Tullamarine Airport at 05:05 and arrives at San Francisco Intl. Airport at 06:30. The last flight of the day departs Melbourne at 23:00 and arrives at San Francisco at 22:30.

The flight distance from Melbourne to San Francisco is about 12845 km, the shortest flight is 16 hours with Virgin Australia.

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