There are several airlines that operate frequent flights from Lisbon (LIS) to Prague (PRG) including

• TAP Portugal with 119 flights a week
• Lufthansa Cargo with 33 flights a week
• Alitalia with 19 flights a week
• Air France with 19 flights a week
• KLM with 17 flights a week

The earliest flight leaves Portela Airport at 01:40 and arrives at Vaclav Havel Airport at 00:05. The last flight of the day departs Lisbon at 20:35 and arrives at Prague at 23:55.

The flight distance from Lisbon to Prague is about 2240 km, the shortest flight is 03 hours 15 minutes with Air Europa.

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