There are several airlines that operate frequent flights from Frankfurt (FRA) to Sao Paulo (GRU) including

• Lufthansa Cargo with 122 flights a week
• Air Berlin with 36 flights a week
• British Airways with 23 flights a week
• Swiss International Air Lines with 21 flights a week
• LATAM Airlines Brasil with 16 flights a week

The earliest flight leaves Frankfurt Intl. Airport at 19:45 and arrives at Guarulhos Governor Andre Franco Montoro Intl. Airport at 04:35. The last flight of the day departs Frankfurt at 22:05 and arrives at Sao Paulo at 07:00.

The flight distance from Frankfurt to Sao Paulo is about 9850 km, the shortest flight is 11 hours 50 minutes with Air Europa.

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