There are several airlines that operate frequent flights from Rome (FCO) to Prague (PRG) including

• Alitalia with 85 flights a week
• Air Berlin with 52 flights a week
• Lufthansa Cargo with 41 flights a week
• Czech Airlines j.s.c with 12 flights a week
• China Southern Airlines with 11 flights a week

The earliest flight leaves Fiumicino Leonardo da Vinci Intl. Airport at 07:55 and arrives at Vaclav Havel Airport at 09:55. The last flight of the day departs Rome at 19:20 and arrives at Prague at 21:15.

The flight distance from Rome to Prague is about 940 km, the shortest flight is 01 hours 50 minutes with Vueling Airlines."

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