There are several airlines that operate frequent flights from Detroit (DTW) to San Francisco (SFO) including

• Delta Air Lines with 377 flights a week
• American Airlines with 102 flights a week
• United Airlines with 99 flights a week
• Qantas Airways with 87 flights a week
• with 80 flights a week

The earliest flight leaves Detroit Metropolitan Wayne County Airport at 08:15 and arrives at San Francisco Intl. Airport at 10:16. The last flight of the day departs Detroit at 20:26 and arrives at San Francisco at 22:59.

The flight distance from Detroit to San Francisco is about 3355 km, the shortest flight is 04 hours 53 minutes with .

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