S$261 Cheap Flights from Medellín to Panama City

View S$261 flight on Thu, 2 Oct, 2025Opens in a new window

Popular airlines from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Medellín to Panama City (MDE-PTY)

Prices were available within the past 7 days and start at S$261 for one-way flights and S$418 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Copa
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$418 Return, found 10 hours ago
S$418
Return
found 10 hours ago
Select Copa flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$418 found 10 hours ago
avianca
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$459 Return, found 10 hours ago
S$459
Return
found 10 hours ago
Select avianca flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$459 found 10 hours ago
Copa
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$463 Return, found 10 hours ago
S$463
Return
found 10 hours ago
Select Copa flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$463 found 10 hours ago
Copa
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$474 Return, found 10 hours ago
S$474
Return
found 10 hours ago
Select Copa flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$474 found 10 hours ago
avianca
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$485 Return, found 10 hours ago
S$485
Return
found 10 hours ago
Select avianca flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$485 found 10 hours ago
Copa
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$493 Return, found 10 hours ago
S$493
Return
found 10 hours ago
Select Copa flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$493 found 10 hours ago
Copa
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$501 Return, found 10 hours ago
S$501
Return
found 10 hours ago
Select Copa flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$501 found 10 hours ago
avianca
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$510 Return, found 10 hours ago
S$510
Return
found 10 hours ago
Select avianca flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$510 found 10 hours ago
avianca
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$512 Return, found 10 hours ago
S$512
Return
found 10 hours ago
Select avianca flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$512 found 10 hours ago
Copa
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$518 Return, found 10 hours ago
S$518
Return
found 10 hours ago
Select Copa flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$518 found 10 hours ago
Copa
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$529 Return, found 10 hours ago
S$529
Return
found 10 hours ago
Select Copa flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$529 found 10 hours ago
Copa
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$531 Return, found 10 hours ago
S$531
Return
found 10 hours ago
Select Copa flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$531 found 10 hours ago
avianca
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$534 Return, found 10 hours ago
S$534
Return
found 10 hours ago
Select avianca flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$534 found 10 hours ago
avianca
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$539 Return, found 10 hours ago
S$539
Return
found 10 hours ago
Select avianca flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$539 found 10 hours ago
Aeromexico
Thu, 2 Oct - Thu, 9 Oct
MDE
Medellin
PTY
Panama City
S$949 Return, found 10 hours ago
S$949
Return
found 10 hours ago
Select Aeromexico flight, departing Thu, 2 Oct from Medellin to Panama City, returning Thu, 9 Oct, priced at S$949 found 10 hours ago

Find the cheapest month to fly from Medellín (MDE) to Panama City (PTY)

March is typically the cheapest month to fly

From S$262 - S$478 per traveller.

Graph displaying average flight prices per month

Medellín to Panama City route information
Origin airport
José María Córdova Intl.
Destination airport
Tocumen Intl.
Return price
S$418
Distance
539 km
Average flight time
1 hour 26 mins

Perfect flights from Medellín to Panama City

Your Journey from Medellín to Panama City

Start your unforgettable journey with Expedia. Our broad selection of flights from Medellín to Panama City caters to every travel need. Whether you're yearning for a romantic escape, a solo adventure, or a cultural immersion, we've got you covered.
 

Choosing Your Ideal Flight

With Expedia, you have access to a wide range of airlines, including avianca, Copa, Aeromexico. Our selection of flights from José María Córdova Intl. to Tocumen Intl. caters to every traveler's requirements, ensuring your journey aligns with your schedule. With options from 20 airlines, you're bound to find the perfect flight.
 

Maximizing Value with Medellín to Panama City Flights

Experience the joy of finding cheap flights from José María Córdova Intl. to Tocumen Intl. that fit your budget. Keep an eye out for our special deals and discounts, and check our flexible one-way fares from S$261 and roundtrip prices from S$418*.
 

Pre-Flight Essentials

Ensure a smooth journey from Medellín to Panama City with Expedia. From information about check-in times and in-flight amenities to guidance on baggage policies, we provide all the essentials to prepare you for your flight.
 

Experience the Vibrant Panama City

Picture yourself stepping off the plane in Panama City and immersing yourself in the unique atmosphere of . From local markets to cultural festivals, each city offers its distinct charm. Make the most of your trip by exploring local attractions and indulging in the local cuisine. With Expedia, explore all this and more, tailored to your budget.
 

Added Convenience on Your Medellín to Panama City Flight

Traveling with Expedia is more than just a flight. We offer details about in-flight amenities, baggage policies, and more to ensure a smooth and hassle-free journey. Choose from our variety of airlines and embark on a memorable journey from Medellín to Panama City.
 

Beyond the Flight – Exploring Panama City

With Expedia, your adventure extends beyond the flight. Explore Panama City at your own pace by renting a car or booking a hotel. Discover hidden gems off the beaten path and create unforgettable memories.
 

Book Your Flight from Medellín to Panama City with Confidence

Planning your next great adventure is a breeze with Expedia. Our user-friendly platform, unbeatable prices, and round-the-clock customer support make your travel experience seamless and stress-free. Embark on your journey from Medellín to Panama City with confidence. Book your travel arrangements with Expedia today.
 
*Note: Prices may vary based on availability and are subject to change.

Frequently asked questions

How much is a flight from Medellin Airport to Tocumen Intl. Airport (PTY)?
Start packing your bags, because round-trip flights from Jose Maria Cordova Intl. Airport (MDE) to Panama Airport start from S$418. That's based on fares listed within the last 7 days on Expedia for flights departing within the next year. Prices can move quickly, so book now to score the best deal. Prices and availability are subject to change. Additional terms apply.
Do I need to pay a cancellation fee if I cancel my flight from MDE to PTY?
The majority of flights can be cancelled online, but whether you incur a fee all comes down to your airline. If you do have to cancel your break, follow the easy instructions in the Customer Service Portal.
How do I find cheap flights from Medellin Airport to Panama Airport that have flexible change policies?
Many airlines offer the option to reschedule your flight without a change fee. All you pay is the difference between the original flight and the new flight. When you're searching for Medellin Airport to PTY flights, you'll see a "no change fees" filter for you to select.
How far is the flight from Medellin Airport to Panama Airport?
A flight distance of just 540 kilometres separates Rionegro and Tocumen. Once you're in the air, you won't get a chance to do much more than browse the magazine in your seat-back pocket.
Which airlines fly direct from Jose Maria Cordova Intl. Airport (MDE) to Tocumen Intl. Airport (PTY)?
Copa Airlines (CM) is one of the preferred choices for many travellers flying between Medellin Airport and Tocumen Intl. Airport (PTY). Choose from the 199 flights it offers on this route each month. You could also have a look at fares with Copa Airlines Colombia (P5). It operates 13 flights a month between Rionegro and Tocumen.
Are MDE to Panama Airport flight tickets cheaper when they're purchased at the last minute?
Booking your trip from Jose Maria Cordova Intl. Airport (MDE) to Panama Airport last minute could be your ticket to an awesome deal. However, it might cost you a whole lot more! If you'd rather not take any chances, book well ahead of your departure date. In fact, Expedia has some of the biggest bargains up to 12 months in advance. If your preferred carrier hasn't released tickets yet, check back regularly as deals are updated on Expedia all the time.

Explore a world of travel with Expedia

*Available to Expedia members.