If you're looking forward to lots of outings with your partner, take a look at these details about year-round temperatures in Santa Fe de Antioquia: The hottest months are usually August and July, with an average temperature of 19°C, while the coldest months are December and January, with an average of 18°C. The rainiest months in Santa Fe de Antioquia are May, April, October and November, with each month seeing an average of 406 mm of rainfall.