What's it like in Sant' Ambrogio?

Guests are sure to enjoy their time checking out all that Florence's Sant' Ambrogio neighbourhood has to offer. Make sure that you visit Great Synagogue of Florence and Piazza Massimo D'Azeglio as part of your Sant' Ambrogio travel plans.

What's a favourite hotel to stay in Sant' Ambrogio?

Based on Expedia customer reviews, Alfieri9 is the highest ranked property in Sant' Ambrogio. This hotel is a short 12-minute walk from Gallery of the Academy of Florence, and it offers free WiFi and valet parking. Other favourite options in the area include Hotel Regency and B&B di Piazza del Duomo .

How many hotels can I expect to find in Sant' Ambrogio?

If you're searching for places to stay in Florence, Expedia has something to meet your needs with 494 Sant' Ambrogio hotels and other accommodation options to choose from.

If I need to cancel my hotel reservation in Sant' Ambrogio, will I receive a refund?

Yes, you'll find most hotel room reservations are fully refundable if you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of your arrival date. If you have a non-refundable reservation, it might still be possible to cancel it and receive a refund within a 24-hour period of booking. Add your dates and click on "Search", then use the "fully refundable" filter to get the best options available in Sant' Ambrogio.

What is there to do around this Florence neighbourhood?

Landmarks in Sant' Ambrogio that you won't want to miss include Great Synagogue of Florence and Church of Santa Maria Maddalena dei Pazzi. Piazza Massimo D'Azeglio and Jewish Museum are also a couple of places to visit in the neighbourhood. Cathedral of Santa Maria del Fiore and Uffizi Gallery are some popular places to visit in the area around Sant' Ambrogio. When you're sightseeing in Florence, Church of Sant'Ambrogio and FiesoleBike Day Tours are also worth a stop.

Top 10 Sant' Ambrogio Hotels of 2025

Top 10 Hotels in Sant' Ambrogio

"Lovely hotel in a historical building. "

includes taxes & fees

15 Aug - 16 Aug

In-room safe, blackout curtains, soundproofing, free WiFi

"I like the place here, very affordable price and also friendly staffs. We enjoyed staying in Florence, beautiful it’s the most iconic sights architecture and culture. "

"Cute hotel & great staff. Would stay here again! "

"Comfortable clean room with original ceiling from 1611, unexpected complimenary prosecco, crossaints, coffee and juice machine despite not paying for breakfast. Good view at rooftop terrace, nice staff and perfect location."

includes taxes & fees

24 Aug - 25 Aug

"Absolutely loved our stay here. The terrace French doors and the high ceilings made me feel like I a Victorian princess. I loved opening the doors and the patio doors for the view and for breeze. There are stairs to the property and you have to check in a bloc or two away so be prepared to walk but with the stairs came a ton of safety!!! Four locks to get through. Felt super safe here. I also loved how we were in the heart of Florence but from the back patio it was so quiet you didn’t hear any...

includes taxes & fees

31 Aug - 1 Sept

"This truly is a boutique hotel - the staff, the attention to detail, the design made for such a wonderful curated experience and memorable stay. We were made to feel so welcome, Manuela the manager is extraordinary! We didn't want to leave and will most certainly be back. "

includes taxes & fees

23 Aug - 24 Aug

"Wonderful, spacious room which was clean and comfortable. Staff were lovely and breakfast was great. Location was good for walking and catching transport. Highly recommend."

includes taxes & fees

1 Sept - 2 Sept

"Loved it! Great place and very convenient "

includes taxes & fees

23 Aug - 24 Aug

"Great location, the room was all we needed for the time we had there"

includes taxes & fees

12 Aug - 13 Aug

includes taxes & fees

17 Aug - 18 Aug

3 bedrooms, premium bedding, down duvets, desk

"We loved this property, it looked exactly like the photos, the room was very clean, spacious and beautiful. My partner and I had such a wonderful time. Staff was incredible at the front desk with any questions we had as well as booking us a taxi for our early morning train when we left. This hotel was walkable to many incredible restaurants as well as the Duomo in Florence. We will be recommending this Hotel to anyone traveling through Florence. "

1 bedroom, minibar, individually decorated, individually furnished

"Beautiful property! Loved our stay here! "

"Clean place, friendly and helpful staff. Wish they had elevators."

includes taxes & fees

12 Aug - 13 Aug

Daily buffet breakfast (EUR 7.00 per person)

"Convenience"

Daily buffet breakfast (EUR 8 per person)

"Room was very comfortable and a short walk away from attractions "

"Great location and nice room. Great communication from agents "

1 bedroom, premium bedding, down duvets, laptop workspace

"Will visit again 10/10"

"Great staff and location."

"Excellent location bit a bit noisy at night."

includes taxes & fees

12 Aug - 13 Aug

"Location "

includes taxes & fees

10 Aug - 11 Aug

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Where to stay in Sant' Ambrogio

Find the best Sant' Ambrogio areas for the activities you enjoy most.

Historic Centre of Florence

10 out of top 10 points of interest in this area

Known for its fascinating museums, stunning cathedral and stunning river views, there's plenty to explore in Historic Centre of Florence. Top attractions like Cathedral of Santa Maria del Fiore and Uffizi Gallery are major draws. Catch the metro at Unità Tram Stop or Valfonda - Stazione Santa Maria Novella Tram Stop to see more of the city.

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Duomo

Visitors to Duomo rave about its fascinating museums, stunning cathedral and popular shops. You might also want to make some time to see Cathedral of Santa Maria del Fiore or Uffizi Gallery while you're exploring the neighbourhood.

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Santa Maria Novella

Enjoy the popular shops in Santa Maria Novella. The New Florence Opera House is a worthwhile stop, and you can jump on the metro at Porta al Prato - Leopolda Tram Stop or Fratelli Rosselli Tram Stop to see more of Porta al Prato.

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