Photo by Dr__Vlad

O Brien Hotels from from S$90

  • Plan, book, stay with confidence

  • bex rewards loyalty icon
    Be picky
    Search almost a million properties worldwide
    payments icon
    Treat yourself
    Sign in to save 10% or more on thousands of hotels
    today icon
    Change your mind
    Book hotels with free cancellation

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Property class

Top 10 trending O Brien hotels

Hampton Inn & Suites Alachua I-75

2.5 star property
9.6 out of 10, Exceptional, (390)
"Not cheap, but excellent quality. I think the staff is the strong suit here. "
The price is S$178
includes taxes & fees
20 Apr - 21 Apr
Hampton Inn & Suites Alachua I-75

Americas Best Value Inn Alachua

2.0 star property
4.8 out of 10, (533)
"Property needs full renovation"
The price is S$103
includes taxes & fees
25 Mar - 26 Mar
Americas Best Value Inn Alachua

Royal Inn

2.0 star property
7.2 out of 10, Good, (169)
"It's a very old hotel but economically priced and the front desk employee, maybe owner, was very friendly and quick. The bathroom definitely needs updating or a better clean. We chose not to shower due to looking like mold. It may have been a stain as the rest of the room was clean. "
The price is S$224
includes taxes & fees
30 Mar - 31 Mar
Royal Inn

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 star property
9.2 out of 10, Wonderful, (1004)
"Everything was great"
The price is S$199
includes taxes & fees
13 Apr - 14 Apr
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Vista Verde Farm Retreat

2.0 star property
10.0 out of 10, Exceptional, (2)
"Park right next to the tiny home. It was clean and spacious. Bring a marshmallow/hotdog stick! "
The price is S$251
includes taxes & fees
25 Mar - 26 Mar
Vista Verde Farm Retreat

BlueGem Motel

2.0 star property
9.2 out of 10, Wonderful, (338)
"Nice and very clean "
The price is S$151
includes taxes & fees
25 Mar - 26 Mar
BlueGem Motel

Palms Garden Inn

2.0 star property
7.4 out of 10, Good, (527)
"We stayed for 1 night on a long trip, and it was comfortable and dog friendly with a nice big area to run around with the dog. We would definitely stay again."
The price is S$101
includes taxes & fees
25 Mar - 26 Mar
Palms Garden Inn

The Blanche

2.0 star property
9.2 out of 10, Wonderful, (120)
"Beautiful historic property... very clean."
The price is S$263
includes taxes & fees
25 Mar - 26 Mar
The Blanche

Days Inn by Wyndham Lake City I-10

2.0 star property
6.8 out of 10, (1000)
"Clean, well priced, close to interstate "
The price is S$109
includes taxes & fees
27 Mar - 28 Mar
Days Inn by Wyndham Lake City I-10

Postcard Cabins Gilchrist Springs

2.0 star property
10.0 out of 10, Exceptional, (7)
"Nice clean"
The price is S$165
includes taxes & fees
10 Apr - 11 Apr
Postcard Cabins Gilchrist Springs

Super 8 by Wyndham Lake City

2.0 star property
7.0 out of 10, Good, (598)
"Was able to book within five mins and right to my room "
The price is S$129
includes taxes & fees
25 Mar - 26 Mar
Super 8 by Wyndham Lake City

Driftwood Inn

2.0 star property
7.8 out of 10, Good, (727)
"This was a bare bones hotel. The room was clean and the beds were comfortable. There was Wi-Fi and a tv, and not much else. If all you want is a comfortable bed, then this is the place for you. "
The price is S$103
includes taxes & fees
1 Apr - 2 Apr
Driftwood Inn

Regal Inn

2.5 star property
8.6 out of 10, Excellent, (478)
"Room was nice and clean. Lady on reception was very pleasant."
The price is S$99
includes taxes & fees
7 Apr - 8 Apr
Regal Inn

Courtyard By Marriott Lake City

3.0 star property
9.8 out of 10, Exceptional, (42)
"Great, new hotel! My only complaint is that (as of March 17, 2025) the restaurant isn’t actually open yet."
The price is S$161
includes taxes & fees
6 Apr - 7 Apr
Courtyard By Marriott Lake City

Days Inn by Wyndham Lake City I-75

2.0 star property
7.4 out of 10, Good, (1005)
"Okay "
The price is S$110
includes taxes & fees
30 Mar - 31 Mar
Days Inn by Wyndham Lake City I-75

Knights Inn Lake City

1.5 star property
5.4 out of 10, (603)
"Nice 👍🙂"
The price is S$90
includes taxes & fees
25 Mar - 26 Mar
Knights Inn Lake City

Holiday Inn & Suites Lake City by IHG

3.0 star property
8.4 out of 10, Very good, (1001)
"The hotel was so fresh and clean. The beds were amazing. Right across the street from Cracker barrell and I 75 super close. Love it"
The price is S$149
includes taxes & fees
13 Apr - 14 Apr
Holiday Inn & Suites Lake City by IHG

Quality Inn Lake City

2.5 star property
7.8 out of 10, Good, (845)
"Clean room, comfortable bed, pillows, and bedding, good breakfast-waffles, egg, cheese, and bacon burritos, cereal, toast, muffins, yogurt, hard boiled eggs, easy parking Coffee in lobby was good, but not what was in the room"
The price is S$118
includes taxes & fees
13 Apr - 14 Apr
Quality Inn Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 star property
8.8 out of 10, Excellent, (1005)
"Always love the conviene right off I75. "
The price is S$164
includes taxes & fees
6 Apr - 7 Apr
La Quinta Inn & Suite by Wyndham Lake City

Rodeway Inn Lake City I-75

2.0 star property
6.6 out of 10, (370)
"quite "
The price is S$101
includes taxes & fees
31 Mar - 1 Apr
Rodeway Inn Lake City I-75
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Don't see what you're looking for?
See all available properties in O Brien
Save an average of 15% on thousands of hotels when you're signed in

Learn more about O Brien

Explore attractions like Suwannee River and Ichetucknee River as you discover things to see and do in O Brien.

Photo by Dr__Vlad
Open Photo by Dr__Vlad

Frequently asked questions

Where is the best place to stay in O Brien?

La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay, based on our traveller data. Two other options for your trip to the area are Courtyard By Marriott Lake City and Americas Best Value Inn Lake City. See all available top hotels, or vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel bookings are refundable if you cancel before the hotel’s cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, you might be able to still cancel and receive a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

What's the best hotel for a romantic holiday to O Brien?

Your Safari on the Suwannee River is a favourite property for couples, and features in-room kitchens and private patios.

What's the best pet-friendly place to stay in O Brien?

Your Safari on the Suwannee River is a top property for people travelling with their pets and offers in-room kitchens for its human guests.

What are some accommodation options with pools in O Brien?

La Quinta Inn & Suite by Wyndham Lake City: Features on-the-go, an indoor pool and free self parking. Courtyard By Marriott Lake City and Americas Best Value Inn Lake City are two additional hotels that feature an on-site pool. View all hotels with pools in O Brien.

How is it to stay in O Brien?

Visitors to O Brien will definitely find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodation options to choose from. Find out more about O Brien.

What are the top places to visit in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and Lafayette Blue Springs State Park in the area. Take a look at what more there is to see and do in Expedia's O Brien guide.

What's the seasonal weather in O Brien?

The hottest months are usually July and August, with an average temperature of 27°C, while the coldest months are January and February, with an average of 14°C. Average annual precipitation for O Brien is 1278 mm.