Mesopotamia Holidays

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Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.
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Top hotels in Mesopotamia

O2 Hotel Gualeguaychú
O2 Hotel Gualeguaychú
2.5 out of 5
115 3 de Febrero, Gualeguaychú, Entre Ríos
Fully refundableReserve now, pay when you stay
The price is S$53 per night from 22 Dec to 23 Dec
S$53
includes taxes & fees
22 Dec - 23 Dec
7.4/10 Good! (43 reviews)
"Newly remodeled. Simple (no TV). Clean. Good A/C. Basic breakfast. Friendly staff. Nice rooms. Wifi was non-existent in the room on the 5th floor (despite the front desk resetting their routers), but great everywhere else. The place is in a nice and safe area with nearby restaurants. It’s not 10 ..."

Reviewed on 12 Feb,2024

O2 Hotel Gualeguaychú
Hathor Concordia
Hathor Concordia
3 out of 5
Ruta Nacional 14-km 264.5, Concordia, Entre Rios
The price is S$90 per night from 24 Nov to 25 Nov
S$90
includes taxes & fees
24 Nov - 25 Nov
8.4/10 Very Good! (321 reviews)
"The hotel was very clean and quiet. It was a great stop in between Buenos Aires and Puerto Iguazu!! The restaurant had delicious food and great service and a nice selection of wine and beer. The front desk was very welcoming and answered all questions. Also the room itself was clean and had safety ..."

Reviewed on 14 Mar,2024

Hathor Concordia
Costarenas Hotel & Spa
Costarenas Hotel & Spa
3.5 out of 5
12 de Abril y Quiros, Colon, Entre Rios
Fully refundableReserve now, pay when you stay
The price is S$195 per night from 22 Nov to 23 Nov
S$195
includes taxes & fees
22 Nov - 23 Nov
8.6/10 Excellent! (54 reviews)
Nice area, okay hotel
"The hotel is in a nice area, right by the water. Lots of restaurants within walking distance. The hotel itself was ok- not especially nice but not unclean. The hotel gave us 2 free drink coupons which we appreciated. At night there was a live band in the bar/lobby area. The hotel seemed overpriced ..."

Reviewed on 26 Jul,2019

Costarenas Hotel & Spa
See all 457 properties in Mesopotamia
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Mesopotamia holiday package cost?
Maybe less than you might think — from only , actually! By combining hotels, flights and car rentals into your own tailor-made package, your Mesopotamia escape is just a few clicks away.
How do I get a cheap travel package to Mesopotamia?
Crafting your own Mesopotamia holiday package with Expedia is a great way to save. We offer more than 550 partner airlines and 1,000,000 hotels across the globe. With such a broad range to choose from, you’ll have no worries creating your next dream adventure.
What are the top hotels in Mesopotamia?
Costarenas Hotel & Spa and Hotel Queguay know how to make their guests feel welcome in Colon. If your itinerary also includes Parana, check out Mayim Hotel Termal & Spa and Costarenas Hotel & Spa. Both are very popular with travellers.
How far in advance should I book my Mesopotamia holiday?
It all depends on the airline, but you can usually compare international fares on Expedia nearly a year in advance. While it’s generally a good idea to book ahead of time, lucky travellers occasionally nab a cheaper ticket just weeks before departure dates.
What does an Expedia Mesopotamia travel package include?
You can choose from a combination of hotels, rental cars and flights. Once you’ve made your booking, you can add the fun stuff like experiences and activities. Want to pick your fare class? That’s also easy to do. The choice is all yours when it comes to arranging your perfect Mesopotamia trip.
What should I know before booking a Mesopotamia travel package?
Booking all the parts of your getaway together is a smart way to save. Bundle your flights, car rentals and hotels into a convenient package. But it’s not just hotels. Expedia has all types of properties, including holiday rentals such as mountain cabins and serviced residences. The list is almost endless!
Can I choose my airline with a Mesopotamia Expedia holiday package?
Yes, and with over 550 airlines to select from worldwide, you’re not short on choice. Search the available options and find out which airline fits your budget and needs.
If I'm not able to travel, can I cancel my Mesopotamia holiday package?
Don’t worry if you’re rethinking your Mesopotamia holiday package — you can cancel or amend your booking. And if you’ve booked it within 24 hours, you may be able to do it for free. However, bookings made more than 24 hours ago may incur fees from your hotel, airline or car rental company. We realise life can throw the occasional spanner in the works, so head to our Customer Service Portal if that occurs. When you’re ready to make changes, we’ll take care of it.

Popular places to visit

El Palmar National Park

El Palmar National Park

Explore the great outdoors at El Palmar National Park, a lovely green space in Ubajay.

El Palmar National Park

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.