Find Luxury Hotels in Main Street Hyannis

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Top Luxury Hotels in Main Street Hyannis

Hyannis Plaza Hotel

2.5 star property
6.8 out of 10, (676)
"!"
The price is S$127
includes taxes & fees
26 Dec - 27 Dec
Hyannis Plaza Hotel

Americas Best Value Inn & Suites Hyannis Cape Cod

2.0 star property
7.4 out of 10, Good, (1063)
"Good"
Americas Best Value Inn & Suites Hyannis Cape Cod

Cape Cod Inn

2.0 star property
8.8 out of 10, Excellent, (422)
"The Cape Cod Inn is a decent motel. The rooms are clean and spacious and quiet. We found it very convenient to park outside our door. It’s a very short walk to restaurants and shops and a ten minute walk to the ferry to either Nantucket or Martha’s Vineyard. Good value for the money, would definitely stay again. "
Cape Cod Inn

Comfort Inn Hyannis - Cape Cod

2.5 star property
7.6 out of 10, Good, (1107)
"Great "
The price is S$128
includes taxes & fees
11 Dec - 12 Dec
Comfort Inn Hyannis - Cape Cod
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

Are you looking for a luxury hotel for your stay in Main Street Hyannis?
During your visit, you might want to enjoy the beaches and shopping which Main Street Hyannis is known for.
What's the best high-end place to stay in Main Street Hyannis?
Hyannis Plaza Hotel is a luxury hotel with a seasonal outdoor pool and a bar, and it’s a popular choice for Expedia travellers looking for an elegant place to stay.
How many luxury hotels will I be able to find in Main Street Hyannis?
Lie in the lap of luxury during your getaway to Main Street Hyannis in one of Expedia’s 6 luxury hotels.
When can I expect good weather in Main Street Hyannis?
Planning for the weather is an important factor for making your trip to Main Street Hyannis a success, especially when you’re splurging. The hottest months are usually August and July, with an average temperature of 20°C, while the coldest months are February and January, with an average of 3°C. Average annual precipitation for Main Street Hyannis is 1328 mm.
What's there to see and do in Main Street Hyannis?
Experience Main Street Hyannis with a stop at John F. Kennedy Hyannis Museum, Cape Cod Baseball Hall of Fame and Wackenhammer’s Clockwork Arcade. If you have extra time while you’re in the area, you might want to stop by Cape Cod Maritime Museum and Hyannis Harbor.