Santo Tomé Car Rental

Search and Compare from Car Companies in Santo Tomé

Compare car suppliers to unlock big savings, and package your flight, hotel, and car to save even more.

Members save 10% more on select hotels, cars, activities and holiday rentals. Sign up.Opens in a new window

Enjoy maximum flexibility with penalty-free cancellation on most car rentals.

Beautiful view of the beach with palm trees

Black Friday: Members save 30%+

Members save 30%+ on selected hotels until 4 Dec (property time) with our Black Friday deals. Stay by 15 Dec 2025.

Frequently asked questions

What happens if I need to cancel my Santo Tomé car reservation?
Depending on your rental policy, you may be eligible for your money back. Many reservations provide a complete refund if you advise us at least six hours prior to the pickup time. Got any questions? If you can’t find the answer in your confirmation, our Customer Service Portal is available 24/7.
Why should I rent a Santo Tomé car with Expedia?
Expedia is the best place to book a set of wheels. With suppliers in Santo Tomé to choose from, we search high and low to get you fantastic deals. Score savings with our exclusive offers and member prices, and earn rewards with every booking. Save even more when you combine your bookings into a Santo Tomé vacation package. Car rentals, hotels, flights, tours and experiences — Expedia has everything you need in one convenient place.
How do I find the best car rental deals in Santo Tomé with Expedia?
It’s easy to track down an incredible deal with Expedia. Just choose your favorite ride, select your dates and preferred pickup and drop-off locations, and compare offers from trusted rental providers. Make even bigger savings when you bundle your Santo Tomé car rental with hotel or flight bookings.
What do you need to rent a car in Santo Tomé?
Be prepared to present your driver’s license and a credit card when you get to the rental counter. Prior to the pickup date, check with your selected company whether anything else is needed. For example, you may also need to show proof of auto insurance.
Can I drive in Santo Tomé with my U.S. Driver's license?
No, it’s most likely you’ll need an International Driving Permit in addition to a valid U.S. License. With one of those in your wallet, you can motor around Santo Tomé with confidence.
Can I rent a car for a month or longer in Santo Tomé?
Whether you plan to stop in Santo Tomé or journey beyond, it’s easy to reserve a long-term rental with Expedia. Enter your trip information and pick-up/drop-off locations and we’ll find you cheap long-term car rental deals.
Where can I find a Santo Tomé car rental if I am younger than 25?
If you’re a young driver looking for a car rental in Santo Tomé, it’d be wise to check the terms and conditions of the car rental companies you’re interested in. Some may rent to drivers under 25, some may not. Surcharges may apply if you’re between 21 and 24 years of age. To escape any unpleasant surprises at the rental desk, make sure you know what to expect.