Calle 50
Visit Calle 50
Tours & day trips
See all 53 activities
City Sightseeing Panama City Hop-On Hop-Off Bus Tour
Private & custom tours
See all 9 activities
Private Half-Day Panama City Tour And Panama Canal
Cruises & boat tours
See all 7 activities
Panama Canal Partial Transit
Popular places to visit
Soho City Center
You can enjoy retail therapy at Soho City Center during your trip to Panama City. Discover the area's casinos or seek out its local tours.
Multiplaza Pacific Mall
During your trip to Panama City, you can search for that perfect souvenir at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Avenida Balboa
You can browse for the perfect souvenirs at Avenida Balboa during your stay in Panama City. While you're in the area, wander around the natural setting.
Uruguay Street
During your visit to Panama City, you can search for that perfect souvenir at Uruguay Street. While in this family-friendly area, you can savour the top-notch restaurants.
Bingo 90
Why not roll the dice with a visit to Bingo 90 during your travels in Panama City? Visit the casinos and shops in this vibrant area.
National Shrine of the Heart of Mary
You can learn about the history of Panama City with a trip to National Shrine of the Heart of Mary. Stroll along the seaside or visit the casinos in this vibrant area.
Top Calle 50 Hotel Deals
Hotel Riu Plaza Panama
Megapolis Hotel Panamá
Sheraton Grand Panama
JW Marriott Panama
Decapolis Hotel Panama City
Riande Urban Hotel
Hospedium Princess Hotel Panama
Las Americas Golden Tower Panama
The Executive Hotel
Explore a world of travel with Expedia
Explore a world of travel with Expedia
- Holidays and getaways similar to Calle 50
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- More Hotel Options in Calle 50
- Las Americas Golden Tower Panama
- The Executive Hotel
- Courtyard by Marriott Panama Multiplaza Mall
- Ramada Plaza By Wyndham Panama Punta Pacífica
- AC Hotel by Marriott Panama City
- Holiday Inn Panama Distrito Financiero by IHG
- Novotel Panama City
- Plaza Paitilla Inn Hotel
- Sortis Hotel, Spa & Casino, Autograph Collection by Marriott
- Waldorf Astoria Panama
- Hyatt Regency Panama City
- W Panama
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Book Flight + Lodging, save up to 100% of flight price - Savings based on flight + lodging package prices as compared to the price of the same components available for booking separately before all discounts and rewards applied. Your bundled savings cover up to 100% of your flight. Savings vary based on origin/destination, length of trip, stay dates and travel suppliers. Savings not available on all flight + lodging package bookings.